Synthesis of α-Arylated Esters from Aryl Halides

作     者：Wei DENG Ye Feng WANG Lei LIU Qing Xiang GUO 

作者机构：Department of Chemistry University of Science and Technology of China Hefei 230026 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2006年第17卷第5期

页      面：595-598页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：NNSFC(20332020 20472079) 

主　　题：Cross coupling reaction CuI ethyl acetoacetate aryl halide α-arylalkanoic acids. 

摘      要：An operationally simple and inexpensive catalyst system was developed for the cross coupling of aryl iodides and bromides with ethyl acetoacetate by using CuI as catalyst and Nmethyl glycine as ligand. The reaction represents a novel Cu-catalyzed C-C cross coupling reaction. This procedure is applicable to the preparation of pharmaceutically important α- arylalkanoic acids.