Synthesis,Mass Spectrometric Studies,and Biological Evaluation of 3,5-Dimethoxyhomophthalic Acid and Related Compounds

作     者：GHULAM Qadeer NASIM Hasan-rama FAN Zhi-jin 

作者机构：Department of Chemistry Quaid-I-Azam University Islamabad 45320 Pakistan State Key Laboratory of Elemento-Organic Chemistry Tianjin Key Laboratory of Pesticide Science Nankai University Tianjin 300071 P. R. China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2007年第23卷第5期

页      面：533-537页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Supported by Higher Education Commission of Pakistan,the National Basic Research Program of China(No.2003CB114402) the National Natrual Science Foundation of China(No.20672062) the Tianjin Natural Science Foundation(No.07JCYBJC01200) 

主　　题：3,5-Dimethoxyhomophthalic acid Naturally occurring isocoumarin Biological evaluation 

摘      要：3,5-Dimethoxyhomophthalic acid was synthesized in four steps from 3,5-dimethoxycinnamic acid via a series of reactions including cyclization of 3-（3＇,5＇-dimethoxyphenyl）propionic acid to 5,7-dimethoxy-1-indanone and oxidative decomposition of methyl-2-hydroxy-2-[5,7-dimethyoxy-1-oxo-1H-inden-2（3H）-ylidene]acetate to 3,5-dimethoxyhomophthalic *** synthesized compounds were characterized by elemental analysis,IR,1H NMR,and *** biological evaluation experiments of 3,5-dimthoxyhomophthalic acid and the related synthesized compounds were also carried *** occurring biologically active isocoumarins were prepared in a single step by the condensation of the homophthalic acid with appropriate acid chlorides.