Predicting dyslipidemia after liver transplantation:A significant role of recipient metabolic inflammation profile
作者机构：Department of SurgeryCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Key Lab of Combined Multi-Organ TransplantationMinistry of Public HealthHangzhou 310003Zhejiang ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2020年第26卷第19期
页 面：2374-2387页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：Supported by the National Natural Science Foundation of China,No.81771713 Zhejiang Provincial Natural Science Foundation of China,No.LR18H030001
主 题：Dyslipidemia Liver transplantation Metabolomics Cytokines Predictive model
摘 要：BACKGROUND Post-transplant dyslipidemia(PTDL)is a common complication in liver recipients and can cause morbidity and threaten graft *** crosstalk between metabolic inflammation and dyslipidemia has been recently ***,the role of grafts’and recipients’metabolic status in the development of PTDL has not been *** To investigate the association of recipients’metabolic inflammation status with PTDL and construct a predictive *** A total of 396 adult patients who received primary liver transplantation between 2015 and 2017 were *** and cytokines were analyzed using recipients’pre-transplant peripheral blood in a training set(n=72).An integrated prediction model was established according to the clinical risk factors and metabolic inflammation compounds and further verified in a validation set(n=144).RESULTS The serum lipid profile took 3 mo to reach homeostasis after liver transplantation.A total of 278(70.2%)liver recipients developed PTDL during a follow-up period of 1.78(1.00,2.97)*** PTDL group showed a significantly lower tumorfree survival and overall survival than the non-PTDL group in patients with hepatocellular carcinoma(n=169).The metabolomic analysis showed that metabolic features discriminating between the PTDL and non-PTDL groups were associated with lipid and glucose metabolism-associated *** metabolites and cytokines differentially expressed between the two groups,interleukin-12(p70)showed the best diagnostic accuracy and significantly increased the predictive value when it was incorporated into the clinical model in both training and validation *** Recipients’pre-transplant serum interleukin-12(p70)level is associated with the risk of PTDL and has potential clinical value for predicting PTDL.
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