Mesenchymal stem cell tracking in the intervertebral disc

作     者：Charles Handley Tony Goldschlager David Oehme Peter Ghosh Graham Jenkin 

作者机构：The Ritchie Centre Monash Institute of Medical Research Monash University Clayton VIC 3168 Australia Department of Neurosurgery Monash Medical Centre Clayton VIC 3168 Australia Department of Neurosurgery St Vincent’s Hospital Fitzroy VIC 3065 Australia Proteobioactives Research Laboratories Brookvale NSW 2100 Australia 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2015年第7卷第1期

页      面：65-74页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Intervertebral disc Stem cells Cell tracking Magnetic resonance imaging Intervertebral disc degeneration 

摘      要：Low back pain is a common clinical problem, which leads to significant social, economic and public health costs. Intervertebral disc(IVD) degeneration is accepted as a common cause of low back pain. Initially, this is characterized by a loss of proteoglycans from the nucleus pulposus resulting in loss of tissue hydration and hydrostatic pressure. Conservative management,including analgesia and physiotherapy often fails and surgical treatment, such as spinal fusion, is required. Stem cells offer an exciting possible regenerative approach to IVD disease. Preclinical research has demonstrated promising biochemical, histological and radiological results in restoring degenerate IVDs. Cell tracking provides an opportunity to develop an in-depth understanding of stem cell survival, differentiation and migration, enabling optimization of stem cell treatment. Magnetic Resonance Imaging(MRI) is a non-invasive, non-ionizing imaging modality with high spatial resolution, ideally suited for stem cell tracking. Furthermore, novel MRI sequences have the potential to quantitatively assess IVD disease, providing an improved method to review response to biological treatment. Superparamagnetic iron oxide nanoparticles have been extensively researched for the purpose of cell tracking. These particles are biocompatible, non-toxic and act as excellent MRI contrast agents. This review will explore recent advances and issues in stem cell tracking and molecular imaging in relation to the IVD.