Pathologic pancreatic endocrine cell hyperplasia
Pathologic pancreatic endocrine cell hyperplasia作者机构：Department of Medicine Cedars-Sinai Medi-cal Center Los Angeles CA 90048 United States Department of Pathology Cedars-Sinai MedicalCenter Los Angeles CA 90048 United States Division of Endocrinology and Carcinoid and Neu-roendocrine Tumor Center Cedars-Sinai Medical Center LosAngeles CA 90048 United States
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2011年第17卷第2期
页 面：137-143页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
主 题：Glucagon receptor Hyperplasia Nesidioblastosis Islet Pancreatic endocrine cell Neuroendocrine tumor
摘 要：Pathologic hyperplasia of various pancreatic endocrine cells is rare but has been long known.β cell hyperplasia contributes to persistent hyperinsulinemic hypoglycemia of infancy,which is commonly caused by mutations in the islet ATP-sensitive potassium channel,and to noninsulinoma pancreatogenous hypoglycemia in adults,which may or may not be associated with bariatric surgery.α cell hyperplasia may cause glucagonoma syndrome or induce pancreatic neuroendocrine *** inactivating mutation of the glucagon receptor causes α cell hyperplasia and asymptomatic *** polypeptide cell hyperplasia has been described without a clearly-characterized clinical syndrome and hyperplasia of other endocrine cells inside the pancreas has not been reported to our knowledge. Based on morphological evidence,the main pathogenetic mechanism for pancreatic endocrine cell hyperplasia is increased endocrine cell neogenesis from exocrine ductal *** endocrine cell hyperplasia should be considered in the diagnosis and management of hypoglycemia,elevated islet hormone levels,and pancreatic neuroendocrine *** studies of pathologic pancreatic endocrine cell hyperplasia will likely yield insights into the pathogenesis and treatment of diabetes and pancreatic neuroendocrine tumors.
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