Comparison of epidemiological and clinical characteristics of COVID-19 patients with and without Wuhan exposure history in Zhejiang Province,China

作     者：Jiang-shan LIAN Huan CAI Shao-rui HAO Xi JIN Xiao-li ZHANG Lin ZHENG Hong-yu JIA Jian-hua HU Shan-yan ZHANG Guo-dong YU Jue-qing GU Chan-yuan YE Ci-liang JIN Ying-feng LU Ji-fang SHENG Yi-da YANG Jiang-shan LIAN;Huan CAI;Shao-rui HAO;Xi JIN;Xiao-li ZHANG;Lin ZHENG;Hong-yu JIA;Jian-hua HU;Shan-yan ZHANG;Guo-dong YU;Jue-qing GU;Chan-yuan YE;Ci-liang JIN;Ying-feng LU;Ji-fang SHENG;Yi-da YANG

作者机构：State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesNational Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesDepartment of Infectious Diseasesthe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Department of Gastroenterologythe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2020年第21卷第5期

页      面：369-377页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：the National Major Science and Technology Research Projects for the Control and Prevention of Major Infectious Diseases in China(No.2017ZX10202202) the National Natural Science Foundation of China(No.81770574) 

主　　题：Coronavirus disease 2019(COVID-19) Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Zhejiang Province Wuhan 

摘      要：Background:A novel coronavirus called severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),first identified in Wuhan,China,has been rapidly spreading around the *** study investigates the epidemiological and clinical characteristics of coronavirus disease 2019(COVID-19)patients in Zhejiang Province who did or did not have a history of Wuhan ***:We collected data from medical records of confirmed COVID-19 patients in Zhejiang Province from Jan.17 to Feb.7,2020 and analyzed epidemiological,clinical,and treatment data of those with and without recorded recent exposure in ***:Patients in the control group were older than those in the exposure group((48.19±16.13)years vs.(43.47±13.12)years,P0.001),and more were over 65 years old(15.95%control vs.5.60%exposure,P0.001).The rate of clustered onset was also significantly higher in the control group than in the exposure group(31.39%vs.18.66%,P0.001).The symptom of a sore throat in patients in the exposure group was significantly higher than that in the control group(17.30%vs.10.89%,P=0.01);however,headache in the exposure group was significantly lower than that in the control group(6.87%vs.12.15%,P=0.015).More patients in the exposure group had a significantly lower level of lactate dehydrogenase(LDH)and aspartate aminotransferase(AST)than those in the control *** was no significant difference in any degree of COVID-19 including mild,severe,and critical between the two ***:From the perspective of epidemiological and clinical characteristics,there was no significant difference between COVID-19 patients with and without Wuhan exposure history.