N-acetylcysteine maintains penile length and erectile function in bilateral cavernous nerve crush rat model by reducing penile fibrosis

作     者：Ming Ma Chang-Jing Wu Peng Zhang Tao Li Shan-Zun Wei Bo-Tao Yu Feng Qin Jiu-Hong Yuan 

作者机构：Andrology LaboratoryWest China HospitalSichuan UniversityChengdu 610041China Department of UrologyWest China HospitalSichuan UniversityChengdu 610041China 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2021年第23卷第2期

页      面：215-221页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：This work was supported by the Natural Science Foundation of China(No.81671453 and No.81871147) the Sichuan Science and Technology Program(No.2018SZ0019 and No.2018TJPT0018) 

主　　题：erectile dysfunction N-acetylcysteine penile fibrosis penile length 

摘      要：Penile length shortening and erectile dysfunction are common complications after radical *** methods have been used to maintain erectile function,but less attention has been paid to preserving penis length.N-acetylcysteine(NAC)has the effect of antioxidation and antifibrotic,which may be beneficial to improve those postoperative *** study investigated the effect of NAC on maintaining the penile length and the erectile function after bilateral cavernous nerve crush(BCNC)and its underlying ***-four male rats were randomly divided into three groups:control group,BCNC group,and BCNC+NAC *** or equal volume of saline was daily administrated by intragastric gavage for 4 *** initial and end penile lengths were *** pressure/mean arterial pressure(ICP/MAP)ratio was calculated to assess erectile ***-eosin staining,Masson s trichrome staining,immunohistochemistry,and Western blot were performed to explore cellular and molecular changes of the *** to the BCNC group,the penile length,ICP/MAP ratio and smooth muscle/collagen ratio in the BCNC+NAC group were improved significantly(all P0.05),and the expressions of endothelial nitric oxide synthase,α-smooth muscle actin,glutathione,and glutathione peroxidase 1 were significantly increased after NAC treated(all P0.05),along with the decreased expressions of hypoxia-inducible factor-1α,transforming growth factor-β1,collagen I,collagen III,collagen IV,malonaldehyde,and lysine oxidase(all P0.05).This study demonstrated that NAC could maintain penile length and partly improve erectile *** mechanism is directly and/or indirectly related to antihypoxic and antifibrosis.