Overlapping Cardiac Programs in Heart Development and Regeneration

作     者：Yi-Song Zhen Qing Wu Cheng-Lu Xiao Nan-Nan Chang Xu Wang Lei Lei Xiaojun Zhu Jing-Wei Xiong 

作者机构：Institute of Molecular MedicinePeking UniversityBeijing 100871China State Key Laboratory of Cardiovascular DiseaseFuwai Hospital&Cardiovascular InstituteChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100037China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2012年第39卷第9期

页      面：443-449页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071008[理学-发育生物学] 08[工学] 09[农学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：supported by the grants from the National Basic Research Program of China(Nos.2010CB529503 and 2012CB944501) the National Science Foundation of China(Nos.30971662 and 31000644) 

主　　题：Cardiac progenitors Heart development Heart regeneration Zebrafish 

摘      要：Gaining cellular and molecular insights into heart development and regeneration will likely provide new therapeutic targets and opportunities for cardiac regenerative medicine,one of the most urgent clinical needs for heart *** we present a review on zebrafish heart development and regeneration,with a particular focus on early cardiac progenitor development and their contribution to building embryonic heart,as well as cellular and molecular programs in adult zebrafish heart *** attempt to emphasize that the signaling pathways shaping cardiac progenitors in heart development may also be redeployed during the progress of adult heart regeneration.A brief perspective highlights several important and promising research areas in this exciting field.