The therapeutic potential of mesenchymal stem cells in Alzheimer's disease:converging mechanisms

作     者：Gadi Turgeman 

作者机构：Department of Pre-Medical Studies & Department of Molecular BiologyAriel University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2015年第10卷第5期

页      面：698-699页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100203[医学-老年医学] 10[医学] 

主　　题：cell stem The therapeutic potential of mesenchymal stem cells in Alzheimer’s disease MSCs 

摘      要：Mesenchymal stem cells （MSCS） are pluripotent stem cells isolated from various tissues, but mostly from bone marrow, adipose tissue, and umbilical cord blood. Well known for their mesenchymal lineages differentiation （e.g., bone, cartilage and fat tissues）, it was suggested that MSCs possess plasticity prop- erties enabling them to differentiate into non-mesenchymal lineages. Indeed, several protocols claimed for differentiating MSCs to neurons in vitro, but concern was raised for the ef- fectiveness and in vivo relevance of such differentiation. Thus, though their neurogenic differentiation properties are still in debate, they were nevertheless, suggested as candidates for treat- ing neurodegenerative disorders such as Parkinson＇s diseases, multiple sclerosis and Alzheimer＇s disease （AD）.