HER-2,P53 and Hormonal Receptors Protein Expression as Predictive Factors in Breast Cancer Prognosis

作     者：Seyed Mohammad Rabiee Hashemi Somayeh Rabiee Hashemi 

作者机构：Department of SurgeryMedical Sciences/University of Tehran General PractitionerIslamic Azad University 

出 版 物：《Chinese Journal of Clinical Oncology》 (中国肿瘤临床（英文版）)

年 卷 期：2008年第5卷第6期

页      面：413-417页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：breast cancer HER-2/neu P53. 

摘      要：OBJECTIVE Breast cancer is a heterogeneous disease with vari-able biological and clinical *** conducted a studyto evaluate P53,HER-2/neu and hormonal receptor expression aspredictors of prognosis in breast *** In a prospective study,we recruited 81 consecutivepatients with primary operable breast cancer who were treatedwith mastectomy followed by locoregional radiotherapy or che-motherapy and studied the presence of P53,HER-2/neu andhormonal receptors (ER/PR) expression in tumor tissues by im-munohistochemical *** between these markersexpression and clinical outcomes,including local and regionalrecurrence and metastasis were *** analysis wasperformed with the SPSS *** The mean time of follow-up was (47.3±4.6) *** of P53,HER-2/neu,Estrogen receptors and progester-one receptors were observed in 31.1%,38.5%,31.8% and 51.7% ofthe patients,respectively.P53,HER-2/neu and Negative ER statuswere potent predictors of local-regional recurrence (P=0.034,0.038,0.044,respectively).Also HER-2/neu,Negative ER and NegativePR status were strong predictors of metastasis (P=0.001,0.042,0.054,respectively).CONCLUSION P53 and HER-2/neu expression and also steroidreceptors status (ER/PR status) have an important role in predict-ing the outcome of breast cancer and thus may be of value in se-lecting suitable therapeutic strategy and determining prognosis inthese patients.