Protective Effect of Procyanidin B2 on Acute Liver Injury Induced by Aflatoxin B1 in Rats

作     者：DENG Zhi Jie ZHAO Jing Fang HUANG Feng SUN Gui Li GAO Wei LU Li XIAO De Qiang DENG Zhi Jie;ZHAO Jing Fang;HUANG Feng;SUN Gui Li;GAO Wei;LU Li;XIAO De Qiang

作者机构：Department of Clinical NutritionThe Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031GuangxiChina Department of Clinical NutritionGuangxi International Zhuang Medicine HospitalNanning 530000GuangxiChina Department of Clinical NutritionLiuzhou General HospitalLiuzhou 545006GuangxiChina Department of Nutrition and Food HygieneSchool of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent DiseasesGuangxi Medical UniversityNanning 530021GuangxiChina 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2020年第33卷第4期

页      面：238-247页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：financially supported by National Natural Science Foundation of China[No.31360383] 

主　　题：Procyanidin B2 Aflatoxin B1 Acute liver injury Oxidative stress Inflammation 

摘      要：Objective This study aimed to explore the protective effect of procyanidin B2(PCB2)on acute liver injury induced by aflatoxin B1(AFB1)in *** Forty Sprague Dawley rats were randomly divided into control,AFB1,AFB1+PCB2,and PCB2 *** latter two groups were administrated PCB2 intragastrically(30 mg/kg body weight)for 7 d,whereas the control and AFB1 groups were given the same dose of double distilled water *** the sixth day of treatment,the AFB1 and AFB1+PCB2 groups were intraperitoneally injected with AFB1(2 mg/kg).The control and PCB2 groups were intraperitoneally administered the same dose of dimethyl sulfoxide(DMSO).On the eighth day,all rats were euthanized:serum and liver tissue were isolated for further *** histological features were assessed by hematoxylin and eosin-stained ***,organ coefficient(liver,spleen,and kidney),liver function(serum alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,total bilirubin,and direct bilirubin),oxidative index(catalase,glutathione,superoxide dismutase,malondialdehyde,and 8-hydroxy-2′-deoxyguanosine),inflammation factor[hepatic interleukin-6(IL-6)m RNA expression and serum IL-6],and bcl-2/bax ratio were *** AFB1 significantly caused hepatic histopathological damage,abnormal liver function,oxidative stress,inflammation,and bcl-2/bax ratio reduction compared with DMSO-treated *** results indicate that PCB2 treatment can partially reverse the adverse liver conditions induced by *** Our findings indicate that PCB2 exhibits a protective effect on acute liver injury induced by AFB1.