Prognostic significance of systemic immune-inflammation index in patients with intrahepatic cholangiocarcinoma undergoing hepatic resection

作     者：Hui Li Jin-Ju Wang Min Zhang Bo Ren Jia-Xin Li Lin Xu Hong Wu 

作者机构：Department of Liver Surgery and Liver TransplantationWest China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina State Key Laboratory of Biotherapy and Cancer CenterSichuan UniversityChengdu 610041Sichuan ProvinceChina Collaborative Innovation Center of BiotherapySichuan UniversityChengdu 610041Sichuan ProvinceChina Department of AnesthesiologyJiulongpo People’s HospitalChongqing 400000China 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2020年第12卷第4期

页      面：467-482页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China,No.81972747,No.81872004,No.81800564,No.81770615,No.81700555 and No.81672882 the Science and Technology Support Program of Sichuan Province,No.2019YFQ0001,No.2018SZ0115 and No.2017SZ0003 the Science and Technology Program of Tibet Autonomous Region,No.XZ201801-GB-02 the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University,No.ZYJC18008 

主　　题：Intrahepatic cholangiocarcinoma Systemic immune-inflammation index Hepatectomy Prognostic predictor Long-term outcomes Immunotherapy 

摘      要：BACKGROUND The prognosis of intrahepatic cholangiocarcinoma(ICC)patients following surgical resection remains *** is necessary to investigate effective biomarkers or prognostic models for ICC *** To investigate the prognostic effect of systemic immune-inflammation index(SII)to predict long-term outcomes in ICC patients with undergoing hepatic *** Consecutive ICC patients who underwent initial hepatectomy with curative intent from January 2009 to September 2017 were retrospectively ***-operating characteristic(ROC)curves were used to determine the optimal cut-off values of ***-Meier curves and Cox proportional hazards regression were performed to evaluate the discriminative ability of preoperative SII in predicting overall survival(OS)and recurrence-free survival(RFS).RESULTS A total of 530 patients were included and randomly divided into derivation(n=265)and validation cohort(n=265).The optimal cut-off value for SII was *** median follow-up of 18 mo(range,1-115.4 mo),317(59.8%)patients died and381(71.9%)patients experienced tumor *** SII level was associated with better OS and RFS(both P0.05).Multivariate analyses identified multiple tumors,node invasion and high SII level as independent risk factors for OS,while multiple tumors,node invasion and high SII level were identified as independent risk factors for *** cohort confirmed the findings of derivation *** The present study demonstrated the feasibility of preoperative SII as a prognostic indicator for *** with increased SII level were associated with worse OS and earlier tumor *** SII level was an independent risk factor for OS and RFS in patients with ICC after *** the future,the SII could help stratifying patients with ICC,thus guiding therapeutic choices,especially in immunotherapy.