S-palmitoylation regulates AMPA receptors trafficking and function: a novel insight into synaptic regulation and therapeutics

作     者：Jun Han Pengfei Wu Fang Wang Jianguo Chen 

作者机构：Department of Pharmacology School of Basic Medicine Tongji Medical College Huazhong University of Science and Technology Laboratory of Neuropsychiatric Diseases The Institute of Brain Research Huazhong University of Science and Technology Key Laboratory of Neurological Diseases (HUST) Ministry of Education of China The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2015年第5卷第1期

页      面：1-7页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by grants from the National Basic Research Program of China (the 973 Program, No. 2013CB531303 to Dr. Jianguo Chen No. 2014CB744601 to Fang Wang) the National Natural Scientific Foundation of China (NSFC, No. 81222048 to Fang Wang No. 81302754 to Peng Fei Wu) supported by the International Science & Technology Cooperation Program of China (No. 2011DFA32670 to Jianguo Chen) PCSIRT (No. IRT13016) 

主　　题：Palmitoylation AMPA receptors Trafficking DHHC 

摘      要：Glutamate acting on AMPA-type ionotropic glutamate receptor(AMPAR) mediates the majority of fast excitatory synaptic transmission in the mammalian central nervous system. Dynamic regulation of AMPAR by post-translational modifications is one of the key elements that allow the nervous system to adapt to environment stimulations. S-palmitoylation, an important lipid modification by post-translational addition of a long-chain fatty acid to a cysteine residue, regulates AMPA receptor trafficking, which dynamically affects multiple fundamental brain functions, such as learning and memory. In vivo, S-palmitoylation is controlled by palmitoyl acyl transferases and palmitoyl *** this review, we highlight advances in the mechanisms for dynamic AMPA receptors palmitoylation,and discuss how palmitoylation affects AMPA receptors function at synapses in recent *** regulation of S-palmitoylation may serve as a novel therapeutic strategy for neurobiological diseases.