The role ofin colorectal cancer: from carcinogenesis to clinical management

作者机构：EquipeCommunicationIntercellulaireetInfectionsMicrobiennesCentredeRechercheInterdisciplinaireenBiologie(CIRB)CollègedeFranceParis75005France ResearchCenterTheSeventhAffiliatedHospitalSunYat-senUniversityShenzhenGuangdong518107ChinaResearchCenterTheSeventhAffiliatedHospitalSunYat-senUniversityShenzhenGuangdong518107China SchoolofBiologicalSciencesNanyangTechnologicalUniversitySingapore637551SingaporeDepartmentofOncologyTheSeventhAffiliatedHospitalSunYat-senUniversityShenzhenGuangdong518107ChinaResearchCenterTheSeventhAffiliatedHospitalSunYat-senUniversityShenzhenGuangdong518107ChinaHealthManagementCenterTheSeventhAffiliatedHospitalSunYat-senUniversityShenzhenGuangdong518107ChinaDepartmentofGastroenterologyTheSecondMedicalCenterofChinesePLAGeneralHospitalBeijing100853ChinaDepartmentofPathologyNationalCancerCenter/NationalClinicalResearchCenterforCancer/CancerHospitalChineseAcademyofMedicalSciencesPekingUnionMedicalCollegeBeijing100021ChinaDepartmentofGeneralSurgeryTheSeventhAffiliatedHospitalSunYat-senUniversityShenzhenGuangdong518107ChinaResearchCenterTheSeventhAffiliatedHospitalSunYat-senUniversityShenzhenGuangdong518107ChinaResearchCenterTheSeventhAffiliatedHospitalSunYat-senUniversityShenzhenGuangdong518107ChinaResearchCenterTheSeventhAffiliatedHospitalSunYat-senUniversityShenzhenGuangdong518107ChinaResearchCenterTheSeventhAffiliatedHospitalSunYat-senUniversityShenzhenGuangdong518107Chin 

出 版 物：《慢性疾病与转化医学（英文）》 (Chronic Diseases and Translational Medicine)

年 卷 期：2019年第3期

页      面：178-187页

核心收录：

学科分类：12[管理学] 1201[管理学-管理科学与工程(可授管理学、工学学位)] 08[工学] 

主　　题：Fusobacterium nucleatum Colorectal carcinoma Carcinogenesis Immune microenvironment Intervention therapy 

摘      要：Colorectal cancer (CRC) is a common malignant tumor that affects people worldwide. Metagenomic analyses have shown an enrichment ofFusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue; many studies have indicated thatF. nucleatum is closely related to the colorectal carcinogenesis. In this review, we provide the latest information to reveal the related molecular mechanisms. The known virulence factors ofF. nucleatum promote adhesion to intestinal epithelial cells via FadA and Fap2. Besides, Fap2 also binds to immune cells causing immunosuppression. Furthermore,F. nucleatum recruits tumor-infiltrating immune cells, thus yielding a pro-inflammatory microenvironment, which promotes colorectal neoplasia progression.F. nucleatum was also found to potentiate CRC development through toll-like receptor 2 (TLR2)/toll-like receptor 4 (TLR4) signaling and microRNA (miRNA)-21 expression. In addition,F. nucleatum increases CRC recurrence along with chemoresistance by mediating a molecular network of miRNA-18a*, miRNA-4802, and autophagy components. Moreover, viableF. nucleatum was detected in mouse xenografts of human primary colorectal adenocarcinomas through successive passages. These findings indicated that an increased number ofF. nucleatum in the tissues is a biomarker for the diagnosis and prognosis of CRC, and the underlying molecular mechanism can probably provide a potential intervention treatment strategy for patients withF. nucleatum-associated CRC.