Exploiting kinase polypharmacology for nerve regeneration

作     者：Hassan Al-Ali John L.Bixby Vance P.Lemmon 

作者机构：Miami Project to Cure Paralysis University of Miami Center for Computational Science University of Miami Department of Neurological Surgery University of Miami Department of Molecular & Cellular Pharmacology University of Miami 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2016年第11卷第1期

页      面：71-72页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：regeneration alterations mature markedly constitute regenerative barriers phenotypic similarity inhibit 

摘      要：The human central nervous system（CNS）has a markedly poor capacity for regenerating its axons following *** appears to be due to two main causes：1）a developmentally regulated decline in regenerative capacity within mature CNS neurons,and 2）the presence of biological components that constitute barriers to axon regeneration（e.g.,growth-inhibitory molecules）.