Induced pluripotent stem cells

作     者：Siddhartha Bhowmik LI Yong 

作者机构：Department of Oral and Maxillofacial Surgery ChongqingStomatological Hospital Chongqing 400015 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2011年第124卷第12期

页      面：1897-1900页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 08[工学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：GermanStateofNorthRhineWestphalia NaturalResourcesWales,NRW DeutscheForschungsgemeinschaft,DFG BundesministeriumfürBildungundForschung,BMBF Max-Planck-Gesellschaft,MPG 

主　　题：induced pluripotent stem cells surface markers cancer free generation of iPS 

摘      要：Induced pluripotent stem （iPS） cells are a recent development which has brought a promise of great therapeutic values. The previous technique of somatic ceil nuclear transfer （SCNT） has been ineffective in humans. Recent discoveries show that human fibroblasls can be reprogrammed by a transient over expression of a small number of genes; they can undergo induced pluripotency, iPS were first produced in 2006. By 2008, work was underway to remove the potential oncogenes from their structure. In 2009, protein iPS （piPS） cells were discovered. Surface markers and reporter genes play an important role in stem cell research. Clinical applications include generation of self renewing stem cells, tissue replacement and many more. Stem cell therapy has the ability to dramatically change the treatment of human diseases.