Understanding the proteome encoded by “non-coding RNAs”:new insights into human genome

作     者：Shaohua Lu Tong Wang Gong Zhang Qing-Yu He Shaohua Lu;Tong Wang;Gong Zhang;Qing-Yu He

作者机构：MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education InstitutesInstitute of Life and Health EngineeringCollege of Life Science and TechnologyJinan UniversityGuangzhou 510632China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2020年第63卷第7期

页      面：986-995页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：supported by the National Key Research and Development Program (2017YFA0505100, 2017YFA0505001, 2018YFC0910202) the National Natural and Science Foundation of China (81372135 to TW 81322028 and 31300649 to GZ 31570828 and 31770888 to Q.Y.H.) 

主　　题：non-coding RNAs Ribo-seq RNC-seq proteome young gene 

摘      要：A great number of non-coding RNAs(ncRNAs) account for the majority of the genome. The translation of these ncRNAs has been noted but seriously underestimated due to both technological and theoretical limitations. Based on the development of ribosome profiling(Ribo-seq), full length translating RNA analysis(RNC-seq) and mass spectrometry technology, more and more ncRNAs are being found to be translated in different organism, and some of them can produce functional peptides. While recently, not only individual new functional proteins, but also a new proteome have been experimentally discovered to be encoded by endogenous lncRNAs and circRNAs. These new proteins are of biological significance, suggesting the connection of the translation of ncRNAs to human physiology and diseases. Therefore, an in-depth and systematic understanding of the coding capabilities of ncRNAs is necessary for basic biology and medicine. In this review, we summarize the advances in the field of discovering this new proteome, i.e. ncRNA-coded proteins.