Catalytic PtPd bimetal nanocrystals with high-index facets for radiation injury repair

作     者：Wei Long Jingya Wang Fujuan Xu Hongying Wu Xiaoyu Mu Junying Wang Yuanming Sun Xiao-Dong Zhang Wei Long;Jingya Wang;Fujuan Xu;Hongying Wu;Xiaoyu Mu;Junying Wang;Yuanming Sun;Xiao-Dong Zhang

作者机构：Key Laboratory of Tianjin Radiation and Molecular Nuclear MedicineInstitute of Radiation MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300192China Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing TechnologySchool of ScienceTianjin UniversityTianjin 300350China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2020年第31卷第1期

页      面：269-274页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 070205[理学-凝聚态物理] 08[工学] 0703[理学-化学] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundation of China (Nos.81673106,81471786 and 91859101) CAMS Innovation Fund for Medical Science (No.2017-12M-1012) 

主　　题：Radiation protection Nanocrystals High-index facets Bimetal Radiation injury 

摘      要：Radiotherapy is one of the most important clinical cancer treatments,which works mainly by delive ring a prescribed radiation dose to the tumor tissues.However,high doses of radiation may also lead many irreversible damages to the surrounding normal tissues.Thereby,how to effectively reduce these sideeffects has been a significant factor in influencing cancer therapeutic effect.In this work,we synthesized the hollow PtPd nanocubes with high-index facets,and investigated the radiation protection capability in vitro and in vivo.Our results showed the PtPd nanocrystals can decrease the ROS level and improve the survival rate of radiated cells.Meanwhile,survival rate of radiated mice can significantly increase from 0 to 30%after PtPd treatment.Consequently,the enzyme and ROS level in radiated mice can be recovered.