Genotype and phylogenetic characterization of hepatitis B virus among multi-ethnic cohort in Hawaii

作     者：Mayumi Sakurai Fuminaka Sugauchi Naoky Tsai Seiji Suzuki Izumi Hasegawa Kei Fujiwara Etsuro Orito Ryuzo Ueda Masashi Mizokami 

作者机构：Department of Clinical Molecular Informative MedicineNagoya City University Graduate School of Medical SciencesNagoya 467-8601Japan Division of GastroenterologyJohn A.Bums School of MedicineUniversity of HawaiiUSA Department of Clinical Internal Medicine and Molecular ScienceNagoya City University Graduate School of Medical SciencesNagoya 467-8601Japan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2004年第10卷第15期

页      面：2218-2222页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：基因型 系统描述 乙型肝炎病毒 多种部队 夏威夷 HBV 重组细胞 

摘      要：AIM: Hepatitis B virus (HBV) genomes in carriers from Hawaii have not been evaluated previously. The aim of thepresent study was to evaluate the distribution of HBV genotypes and their clinical relevance in ***: Genotyping of HBV among 61 multi-ethnicc arriers in Hawaii was performed by genetic *** complete genomes and 61 core promoter/precore regions of HBV were sequenced ***: HBV genotype distribution among the 61 carderswas 23.0% for genotype A, 14.7% for genotype B and 62.3% for genotype C. Genotypes A, B and C were obtained from the carriers whose ethnicities were Filipino and Caucasian,Southeast Asian, and various Asian and Micronesian,respectively. All cases of genotype B were composed of recombinant strains with genotype C in the precore plus core region named genotype Ba. HBeAg was detected more frequently in genotype C than in genotype B (68.4% vs 33.3%, P0.05) and basal core promoter (BCP) mutation (T1762/A1764) was more frequently found in genotype C than in genotype B. Twelve of the 38 genotype C strains possessed C at nucleotide (nt) position 1858 (C-1858).However there was no significant difference in clinical characteristics between C-1858 and T-1858 variants. Based on complete genome sequences, phylogenetic analysis revealed one patient of Micronesian ethnicity as having C1858 clustered with two isolates from Polynesia with *** addition, two strains from Asian ethnidties were clustered with known isolates in carriers from Southeast ***: Genotypes A, B and C are predominant types among multi-ethnic HBV carriers in Hawaii, and distribution of HBV genotypes is dependent on the ethnic background of the carriers in Hawaii.