Serum vitamin D content is associated with semen|parameters and serum testosterone levels in men

作     者：Inari M Ciccone Elaine MF Costa Juliana R Pariz Thiago A Teixeira Joel R Drevet Parviz Gharagozloo Robert J Aitken Jorge Hallak Inari M Ciccone;Elaine MF Costa;Juliana R Pariz;Thiago A Teixeira;Joel R Drevet;Parviz Gharagozloo;Robert J Aitken;Jorge Hallak

作者机构：AndroscienceScience and Innovation Center in Andrology and High-Complex Clinical and Andrology LaboratorySao Paulo 04534-011Brazil Division of UrologyUniversity of Sao PauloSao Paulo 05403-000Brazil Men's Health Study GroupInstitute for Advanced StudiesUniversity of Sao PauloSao Paulo 05508-060Brazil Division of EndocrinologyUniversity of Sao PauloSao Paulo 05403-000Brazil School of MedicineUrology DepartmentFederal University of AmapaMacapa 68903-419Brazil Faculty of MedicineGReD LaboratoryUniversity Clermont Auvergne49Bd Frangois-Mitterrand-CS 6003263001 Clermont-Ferrand CedexFrance Cell0xess LLCEwingNJ 08628USA School of Environmental and Life SciencesPriority Research Centre for Reproductive SciencesUniversity of NewcastleCallaghanNSW 2308Australia Reproductive Toxicology UnitDepartment of PathologyUniversity of Sao PauloSao Paulo 05403-000Brazil 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2021年第23卷第1期

页      面：52-58页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：Androscience  Science and Innovation Center in Andrology and High-Complexity Clinical and Research Andrology Laboratory 

主　　题：male infertility semen quality sexual hormones sperm motility testosterone vitamin D deficiency 

摘      要：The present study aimed to evaluate the influence of serum vitamin D levels on semen quality and testosterone *** is a crosssectional study conducted at Androscience,Science and Innovation Center in Andrology and High-Complex Clinical and Andrology Laboratory in Sao Paulo,Brazil,with 508 male patients,aged 18-60 years,from 2007 to *** parameters and serum sexual hormones were correlated with serum vitamin D concentrations in 260 men selected by strict selection *** were divided into normozoospermic group(NZG,n=124)and a group with seminal abnormalities(SAG,n=136).Evaluation included complete physical examination,past medical history,habits and lifestyle factors,two complete seminal analysis with sperm functional tests,serum levels of 25-hydroxy-vitamin D_(3)(25(OH)VD_(3)),total and free testosterone,luteinizing hormone(LH),follicle-stimulating hormone(FSH),sex hormone-binding globulin(SHBG),total cholesterol,homeostatic model assessment of insulin resistance(HOMA-IR)index,and *** mean concentration of 25(OH)VD_(3)was significantly lower in the SAG(P0.001)and positively correlated with all baseline seminal parameters and total testosterone *** addition,serum vitamin D_(3)concentration was found to be positively correlated with sperm concentration(β=2.103;P0.001),total number of spermatozoa with progressive motility(β=2.069;P=0.003),total number of motile spermatozoa(β=2.571;P=0.015),and strict morphology(β=0.056;P=0.006),regardless of other *** is the first comparative study to address the issue of serum vitamin D_(3)content between normozoospermic patients and those with sperm *** clearly demonstrates a direct and positive relationship between serum vitamin D level and overall semen quality,male reproductive potential,and testosterone levels.