Clinical significance of glycated hemoglobin in the acute phase of ST elevation myocardial infarction
Clinical significance of glycated hemoglobin in the acute phase of ST elevation myocardial infarction作者机构：Intensive Cardiac Care UnitHeart and Vessel DepartmentAzienda OspedalieroUniversitaria Careggi
出 版 物：《World Journal of Cardiology》 (世界心脏病学杂志（英文版）（电子版）)
年 卷 期：2014年第6卷第4期
页 面：140-147页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Glycated hemoglobin ST-elevation myocardial infarction Prognosis Hyperglycemia Glucose intolerance
摘 要：In population-based studies,including diabetic and nondiabetic cohorts,glycated hemoglobin A1c(HbA1c) has been reported as an independent predictor of allcause and cardiovascular disease *** on the prognostic role of HbA1c in patients with acute myocardial infarction(MI) are not univocal since they stem from studies which mainly differ in patients selection criteria,therapy(thrombolysis vs mechanical revascularization) and number *** present review is focused on available evidence on the prognostic significance of HbA1c measured in the acute phase in patients with ST-elevation myocardial infarction(STEMI) submitted to primary percutaneous coronary intervention(PCI).We furthermore highlighted the role of HbA1c as a screening tool for glucose intolerance in patients with *** to available evidence,in contemporary cohorts of STEMI patients submitted to mechanical revascularization,HbA1c does not seem to be associated with short and long term mortality ***,HbA1c may represent a screening tool for glucose intolerance from the early phase on in STEMI *** a pragmatic ground,an HbA1c testhas several advantages over fasting plasma glucose or an oral glucose tolerance test in an acute *** test can be performed in the non-fasting state and reflects average glucose concentration over the preceding 2-3 *** therefore proposed an algorithm based on pragmatic grounds which could be applied in STEMI patients without known diabetes in order to detect glucose intolerance abnormalities from the early *** main advantage of this algorithm is that it may help in tailoring the follow-up program,by helping in identifying patients at risk for the development of glucose intolerance after *** validation of this algorithm in prospective studies may be required in the contemporary STEMI population to resolve some of these uncertainties around HbA1c screening cutoff points.
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