Ultrahigh-sensitive optical coherence elastography
作者机构：Beckman Laser InstituteUniversity of CaliforniaIrvineIrvineCA 92612USA Department of Biomedical EngineeringUniversity of CaliforniaIrvineIrvineCA 92617USA Department of PhysicsKookmin UniversitySeoul 02707South Korea
出 版 物：《Light(Science & Applications)》 (光（科学与应用)（英文版）)
年 卷 期：2020年第9卷第1期
页 面：1470-1479页
核心收录：
学科分类：0808[工学-电气工程] 070207[理学-光学] 0809[工学-电子科学与技术（可授工学、理学学位）] 07[理学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0803[工学-光学工程] 0702[理学-物理学]
基 金：National Institutes of Health(R01EY-026091,R01EY-028662,R01HL-125084,R01HL-127271) American Heart Association(18PRE34050021) the National Science Foundation(DGE-1839285)
主 题：optical interferometer polarization
摘 要：The phase stability of an optical coherence elastography(OCE)system is the key determining factor for achieving a precise elasticity measurement,and it can be affected by the signal-to-noise ratio(SNR),timing jitters in the signal acquisition process,and fluctuations in the optical path difference(OPD)between the sample and reference *** this study,we developed an OCE system based on swept-source optical coherence tomography(SS-OCT)with a common-path configuration(SS-OCECP).Our system has a phase stability of 4.2 mrad without external stabilization or extensive post-processing,such as *** phase stability allows us to detect a displacement as small as~300 pm.A common-path interferometer was incorporated by integrating a 3-mm wedged window into the SS-OCT system to provide intrinsic compensation for polarization and dispersion mismatch,as well as to minimize phase fluctuations caused by the OPD *** wedged window generates two reference signals that produce two OCT images,allowing for averaging to improve the ***,the electrical components are optimized to minimize the timing jitters and prevent edge collisions by adjusting the delays between the trigger,k-clock,and signal,utilizing a high-speed waveform digitizer,and incorporating a high-bandwidth balanced *** validated the SSOCECP performance in a tissue-mimicking phantom and an in vivo rabbit model,and the results demonstrated a significantly improved phase stability compared to that of the conventional *** the best of our knowledge,we demonstrated the first SS-OCECP system,which possesses high-phase stability and can be utilized to significantly improve the sensitivity of elastography.
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