Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea
作者机构：Department of Medical InformaticsCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea College of PharmacySookmyung Women’s UniversitySeoul 04310Republic of Korea Division of Endocrinology and MetabolismDepartment of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Clinical Research Coordinating CenterCatholic Medical CenterThe Catholic University of KoreaSeoul 06591Republic of Korea Department of Preventive MedicineCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea
出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)
年 卷 期：2019年第13卷第6期
页 面：713-722页
核心收录：
基 金：supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute funded by the Ministry of Health & Welfare,Republic of Korea
主 题：statin glomerular filtration rate HMG-CoA reductase inhibitor chronic kidney disease
摘 要：Few long-term follow-up studies have compared the changes in renal function according to the type of statin used in Korea.We compared the long-term effects of statin intensity and type on the changes in the glomerular filtration rate(GFR).We extracted data of patients who took statin for the first time.We analyzed whether or not different statins affect the changes in GFR at 3 months after baseline and 4 years after.We included 3678 patients and analyzed the changes in GFR.The GFR decreased by 3.2%±0.4%on average 4 years after the first statin prescription,indicating statistically significant deterioration(from 83.5±0.4 mL/min/1.73 m2 to 79.9±0.4 mL/min/1.73 m2,P0.001).When comparing the GFR among different statins,significant differences were observed between atorvastatin and fluvastatin(−5.3%±0.7%vs.1.2%±2.2%,P0.05)and between atorvastatin and simvastatin(−5.3%±0.7%vs.−0.7%±0.8%,P0.05).In pitavastatin(odds ratio[OR]=0.64,95%confidence interval[CI]=0.46-0.87,P0.005)and simvastatin(OR=0.69,95%CI=0.53-0.91,P0.008),the GFR rate that decreased by60 mL/min/1.73 m2 was significantly lower than that of atorvastatin.Regarding long-term statin intake,GFR changed with the type of statin.This work is the first in Korea to compare each statin in terms of changes in the GFR after the statin prescription.
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