Effect of Sheng Xue Ning Tablets on Renal Anemia in Patients Subject to Maintenance Hemodialysis and Safety Evaluation: A Multi-setting Prospective Randomized Study

作     者：Xiao-jing TANG Shu RONG Chang-lin MEI Zhao-hui NI Geng-ru JIANG Wei-jie YUAN Nian-song WANG Zhi-yong GUO Jun MA Hai-dong YAN Li-ming ZHANG 

作者机构：Department of NephrologyChangzheng Hospitalthe Second Military Medical UniversityShanghai 20003China Department of NephrologyShanghai General HospitalShanghai Jiao Tong Universiry School of MedicineShanghai 200080China Department of NephrologyRenji HospitalJiaotong UnivrsiryShanghai 200003China Department of NephrologyXin/ua HospitalJiaotong UniversitShanghai 200092China Deparment of Nephrology.the Sixth People's HospitalJiaotong UniversityShanghai 200233China Department of NephrologyChanghai Hospitalthe Second Military Medical UniversityShanghai 200433China Deparment of NephrologyTongji HospitalTongji UniversityShanghai 200065China Deparment of NephrologyEast HospialTongjt UniversiryShanghai 200120China Department of NephrologyZhabei District Cenral HospitalChangzhen HospitalShanghai 200070China 

出 版 物：《Current Medical Science》 (当代医学科学（英文）)

年 卷 期：2020年第40卷第2期

页      面：327-331页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：hemodialysis renal anemia oral iron supplements 

摘      要：This study compared Sheng Xue Ning(SXN)tablets with ferrous succinate(FS)tablets in terms of their efficacy for the treatment of iron-deficient renal anemia and safety in patients subject to maintenance hemodialysis(MHD).A total of 94 patients undergoing MHD were randomly assigned to an experiment group(receiving oral SXN tablcts,SXN group)and a control group(orally given FS tablets,FS group)and followed up for 12 ***(EPO)was used in both *** eficacy was assessed by detecting the subsequent changes in hemoglobin(Hb),serum iron(SI),SF and transferrin saturation(TSAT).At the 12th week,Hb and TSAT levels in both groups were significantly increased compared to those in the screening period(P0.05).However,no significant difference in Hb and TSAT was found between the two *** average weekly EPO dosage used was lower in SXN group than in FS group(P0.05)at the 10th week and the 12th *** study showed that SXN tablets can effectively ameliorate renal anemia and keep iron metabolism stable in MHD patients,and its efficacy is virtually close to that of FS ***,SXN tablets can reduce the dosage of EPO and have a good safety profile.