The level of bile salt-stimulated lipase in the milk of Chinese women and its association with maternal BMI

作     者：Lijun Sha Shanshan Zhou Yangyang Xi Rong Li Xiaonan Li Lijun Sha;Shanshan Zhou;Yangyang Xi;Rong Li;Xiaonan Li

作者机构：Department of Children Health CareChildren's Hospital of Nanjing Medical UniversityNanjingJiangsu 210008China 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2020年第34卷第2期

页      面：122-128页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100404[医学-儿少卫生与妇幼保健学] 10[医学] 

基　　金：supported by grants from the National Basic Research Program of China(973 Program,Grant No.2013CB530604) the key program of the Nanjing Health Bureau(ZKX15043) 

主　　题：bile salt-stimulated lipase breast milk BMI gestational hypertensive disorder gestational diabetes mellitus 

摘      要：This study aimed to investigate the bile salt-stimulated lipase(BSSL) concentration in the milk of Chinese women and its correlation with maternal body mass index(BMI), gestational diabetes mellitus(GDM) and gestational hypertensive disorder(GHD). The BSSL levels in the milk samples were measured by enzyme-linked immunosorbent assay(ELISA). BSSL level in colostrum milk of mothers with full-term infants was positively correlated with pregnancy week and negatively correlated with maternal pre-pregnancy BMI and BMI late in pregnancy. Moreover, the BSSL concentration in mature milk was positively correlated with BMI gain during pregnancy. The BSSL concentration in colostrum milk was lower in GDM mothers than in normal mothers. The BSSL helps infants digest fat in early life and its level was associated with lactation. The changes in BSSL characteristics with maternal BMI and GDM in this study may have clinical implications regarding the effects of pregnancy weight and metabolism on the nutrition and health of the offspring.