Partial Synthesis of Crassicauline A from Yunaconitine

作     者：Rong-Ping Zhang Yan-Jun Lin Hao-Fei Yu Si-Ying Chen Jun Zhou 

作者机构：Yunnan University of Chinese MedicineKunmingChina Kunming Medical UniversityKunmingChina Kunming Institute of BotanyChinese Academy of SciencesKunmingChina 

出 版 物：《Natural Products and Bioprospecting》 (应用天然产物（英文）)

年 卷 期：2020年第10卷第2期

页      面：105-108页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Kunming Institute of Botany  Chinese Academy of Sciences  KIB  CAS  (2020HC008) 

主　　题：Diterpenoid alkaloids Yunaconitine Crassicauline A 

摘      要：Both Aconitum hemsleyanum and Aconitum geniculatun have abundant contents of yunaconitine(1).Yunaconitine(1)has similar skeleton to crassicauline A(3);the only difference between them is that 1 contains aα-hydroxyl group at *** team attempts to convert 1 into 3 because 3 owns pharmacological *** are two steps to achieve the transformation above:firstly,use dehydration reaction to transform yunaconitine(1)into dehydroyunaconitine(2);secondly,use hydrogen reduction to acquire crassicauline A(3).Compared with other methods,this one below is more suitable for production application and more concise;moreover,the cost is lower with higher yield.