Is there still a role for sucralfate in the treatment of gastritis?

作     者：Simon R Bramhall Moustafa M Mourad 

作者机构：Department of SurgeryThe County HospitalHereford HR12ERUnited Kingdom Worcester Royal InfirmaryWorcester WR40JBUnited Kingdom 

出 版 物：《World Journal of Meta-Analysis》 (世界荟萃分析杂志)

年 卷 期：2020年第8卷第1期

页      面：1-3页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Sucralfate Enoscopy Gastritis Treatment Anti-acid 

摘      要：The endoscopic diagnosis of gastritis is usually made when a patient develops symptoms and undergoes an upper gastrointestinal *** are often obvious aetiological causes such as smoking,alcohol Helicobacter pylori infection or drug *** changes can sometimes improve symptoms but often patients will be treated with a proton pump *** stomach mucosa produces a protective mucous to prevent damage cause by gastric acid and exogenous agents can disrupt this *** of this protective layer can be enhanced by reduction in gastric acid secretion using H2 receptor antagonist or proton pump inhibitors or by cytoprotective drugs such as misoprostol,sucralfate,aluminium ions or bismuth *** is a complex polymer which at a low pH changes its chemical configuration and binds to serum protein to form a protective layer protecting the mucosa against further *** drugs were the first line treatment for peptic disease including gastritis for many years but since the launch of cimetidine in 1976 and the subsequent launch of omeprazole in 1988,their use has slowly *** line treatment for patients with symptomatic gastritis after removal of potential causative factors is likely to be a proton pump inhibitor in *** is despite the fact that there is some evidence that sucralfate is superior than a H2 receptor antagonist in the endoscopic healing rates in patients with *** logical treatment choice in patients with resistance symptoms is a combination of a proton pump inhibitor and sucralfate but evidence is *** such evidence is available In the meantime,we would suggest that there is a role for sucralfate in the treatment of intransigent gastritis and that mucosal protection should be considered even ahead of acid suppression given its favourable safety and toxicity profile.