Four natural epothilone derivatives isolated from Sorangium cellulosum strain So0157-2

作     者：鲁春华 赵林 李越中 沈月毛 

作者机构：山东大学药学院教育部化学生物学重点实验室山东济南250012 山东轻工业学院山东省微生物工程重点实验室山东济南250353 山东大学生命科学学院国家微生物技术重点实验室山东济南250010 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2013年第22卷第1期

页      面：28-31页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 10[医学] 

基　　金：National Natural Science Fund for Distinguished Young Scholars (Grant No.30325044,30825001) the 863 Program of China (Grant No.20060102Z1083) 

主　　题：14-Membered epothilones Epoxide opened epothilone Sorangium cellulosum strain So0157-2 

摘      要：Four natural epothilone analogues, including two 14-membered epothilones L （1）, L1 （2） and two epoxide opened epothilones A （3） and B （4）, were isolated from the extract of fermentation adsorber resin of Sorangium cellulosum strain So0157-2. Their structures were elucidated on the basis of comprehensive NMR and MS data. They are all isolated from the wild type S. cellulosum strain So0157-2 as natural products for the first time.