Platelet-rich plasma-induced bone marrow mesenchymal stem cells versus autologous nerve grafting for sciatic nerve repair

作     者：Changsuo Xia Yajuan Li Wen Cao Zhaohua Yu 

作者机构：Department of OrthopedicsAffiliated Hospital of Qingdao University Medical SchoolQingdao 266003Shandong ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2010年第5卷第17期

页      面：1291-1295页

核心收录：

学科分类：090601[农学-基础兽医学] 08[工学] 09[农学] 0906[农学-兽医学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：the Doctoral Scientific Research Program Fund of the Affiliated Hospital of Qingdao University Medical School  No. 2006(doctor)-27 

主　　题：bone marrow mesenchymal stem cells platelet-rich plasma peripheral nerve transplantation tissue engineering 

摘      要：Autologous nerve grafting is the gold standard of peripheral nerve *** previously showed that autologous platelet-rich plasma（PRP）contains high concentrations of growth factors and can induce in vitro cultured bone marrow mesenchymal stem cells（BMSCs）to differentiate into Schwann *** we used PRP-induced BMSCs combined with chemically extracted acellular nerves to repair sciatic nerve defects and compared the effect with autologous nerve *** BMSCs and chemically extracted acellular nerve promoted target muscle wet weight restoration,motor nerve conduction velocity,and axonal and myelin sheath regeneration,with similar effectiveness to autologous nerve *** finding suggests that PRP induced BMSCs can be used to repair peripheral nerve defects.