Determination of isoproterenol in pharmaceutical and biological samples using a pyrogallol red multiwalled carbon nanotube paste electrode as a sensor

作     者：Mohsen Keyvanfard Khadijeh Alizad Mohsen Keyvanfard;Khadijeh Alizad

作者机构：伊斯兰自由大学马杰斯分校化学系 

出 版 物：《Chinese Journal of Catalysis》 (催化学报（英文）)

年 卷 期：2016年第37卷第4期

页      面：579-583页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100704[医学-药物分析学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 10[医学] 

基　　金：Majlesi Branch  Islamic Azad University  for their support 

主　　题：Isoproterenol Pharmaceutical analysis Pyrogallol red Voltammetry Multiwalled carbon nanotubes 

摘      要：Isoproterenol （ISPR） is an important catecholamine‐based drug that is widely used in the treatment of heart disease. However, overdose of this drug is very dangerous to the human body. In this study, a new sensor based on a pyrogallol red modified‐multiwalled carbon nanotube paste electrode （PGRMMWCNTPE） was prepared and used for high sensitivity determination of ISPR in aqueous solution. Electrocatalytic oxidation of ISPR at the PGRMMWCNTPE was investigated by chronoam‐perometry, cyclic voltammetry, and square‐wave voltammetry. The values of the catalytic rate con‐stant, electron transfer coefficient, and diffusion coefficient for ISPR oxidation were then calculated using voltammetric data. A linear calibration curve was constructed for ISPR concentration in the range 0.8–570μmol/L with a detection limit of 0.47μmol/L ISPR. The sensor was then applied to the determination of ISPR in urine and drug samples with satisfactory results.