氢氧化铝纳米片:结构依赖性癌症化疗药物的储运（英文）

作     者：LI Xia SHENASHEN Mohamed A MEKAWY Moataz TANIGUCHI Akiyoshi EI-SAFTY Sherif A LI Xia;SHENASHEN Mohamed A;MEKAWY Moataz;TANIGUCHI Akiyoshi;EI-SAFTY Sherif A

作者机构：Research Center for Functional MaterialsNational Institute for Materials ScienceIbaraki 305-0047Japan Cellular Functional Nanomaterials GroupResearch Center for Functional MaterialsNational Institute for Materials ScienceIbaraki 305-0044Japan Engineering and Advanced ManufacturingUniversity of SunderlandSunderlandUnited Kingdom 

出 版 物：《无机材料学报》 (Journal of Inorganic Materials)

年 卷 期：2020年第35卷第2期

页      面：250-256页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 07[理学] 070205[理学-凝聚态物理] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学] 10[医学] 

基　　金：National Institute for Materials Science of Japan 

主　　题：aluminum hydroxide nanosheet cancer chemotherapy storage drug delivery 

摘      要：Alum has an excellent safety record and is the only licensed inorganic adjuvant for human vaccines.However,the exploration of alum nanosheets as chemotherapy drug delivery system,especially the clarification about the relationship between structures and drug loading properties,is totally insufficient.Herein,aluminum hydroxides(AlOOH)nanosheets with tunable specific surface area and pore size were synthesized by adjusting the synthesis time in the presence of triblock copolymers.The obtained materials exhibited the highest surface area about 470 m2/g.The structure-dependent chemotherapy drug loading capability for AlOOH nanosheets was observed:the higher specific surface area and pore size are,the higher amount of chemotherapy drug is loaded.AlOOH nanosheets loaded with doxorubicin showed a pH-dependent sustained release behavior with quick release in low pH about 5 and slow release in pH around 7.4.Doxorubicin-loaded AlOOH nanosheets exhibited much higher cancer cellular uptake efficiency than that in free form by flow cytometry.Moreover,doxorubicin-loaded AlOOH nanosheets with high specific surface area showed an increased cellular uptake efficiency and enhanced ratios of apoptosis and necrosis,compared with those showing low specific surface area.Therefore,AlOOH nanosheets are promising materials as chemotherapy drug delivery system.