Berberine prevents primary peritoneal adhesion and adhesion reformation by directly inhibiting TIMP-1

作     者：Xin Liu Yunwei Wei Xue Bai Mingqi Li Huimin Li Lei Wang Shuqian Zhang Xia Li Tong Zhao Yang Liu Rui Geng Hao Cui Hui Chen Ranchen Xu Heng Liu Yong Zhang Baofeng Yang Xin Liu;Yunwei Wei;Xue Bai;Mingqi Li;Huimin Li;Lei Wang;Shuqian Zhang;Xia Li;Tong Zhao;Yang Liu;Rui Geng;Hao Cui;Hui Chen;Ranchen Xu;Heng Liu;Yong Zhang;Baofeng Yang

作者机构：Department of Pharmacology(the State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China Department of Oncological and Laparoscopic Surgerythe First Affiliated Hospital of Harbin Medical UniversityHarbin 150001China Institute of Metabolic DiseaseHeilongjiang Academy of Medical ScienceHarbin 150086China Department of Pharmacology and TherapeuticsMelbourne School of Biomedical SciencesFaculty of MedicineDentistry and HealthSciences University of MelbourneMelbourne VIC 3010Australia Research Unit of Noninfectious Chronic Diseases in Frigid ZoneChinese Academy of Medical Sciences2019 Research Unit 070Harbin 150081China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2020年第10卷第5期

页      面：812-824页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Nature Science Foundation of China(81570399 and 81773735) the National Key Research and Development Program of China-Traditional Chinese Medicine Modernization Research project(2017YFC1702003,China) Heilongjiang Outstanding Youth Science Fund(JC2017020,China) 

主　　题：Peritoneal adhesion Berberine Adhesion reformation TIMP-1 

摘      要：Peritoneal adhesions are fibrous tissues that tether organs to one another or to the peritoneal wall and represent the major cause of postsurgical *** at repeat surgeries induces adhesion reformation that is more difficult to prevent than primary *** we studied the preventive effects of different approaches of berberine treatment for primary adhesion,and its effects on adhesion reformation compared to *** found the primary adhesion was remarkably prevented by berberine through intraperitoneal injection 30 min before abrasive surgery(pre-berberine)or direct addition into injured cecum immediately after the surgery(inter-berberine).Rats with adhesion reformation had a more deteriorative collagen accumulation and tissue injury in abrasive sites than rats with primary *** dysregulated TIMP-1/MMP balance was observed in patients after surgery,as well as adhesion tissues from primary adhesion or adhesion reformation ***-berberine treatment had a better effect for adhesion reformation prevention than *** promoted the activation of MMP-3 and MMP-8 by directly blocking TIMP-1 activation core,which was reversed by TIMP-1 overexpression in *** conclusion,this study suggests berberine as a reasonable approach for preventing primary adhesion formation and adhesion reformation.