The therapeutic effect of high-dose esomeprazole on stress ulcer bleeding in trauma patients

作     者：Lihong Cui Chao Li Xiaohui Wang Zhihui Yan Xing He Sandong Gong Cui Lihong;Li Chao;Wang Xiaohui;Yan Zhihui;He Xing;Gong Sandong

作者机构：Department of Gastroenterology Navy General Hospital Beijing 100048 China 

出 版 物：《Chinese Journal of Traumatology》 (中华创伤杂志（英文版）)

年 卷 期：2015年第18卷第1期

页      面：41-43页

核心收录：

学科分类：090603[农学-临床兽医学] 0832[工学-食品科学与工程（可授工学、农学学位）] 0403[教育学-体育学] 1002[医学-临床医学] 08[工学] 09[农学] 0906[农学-兽医学] 

主　　题：溃疡出血 大剂量 应激性 患者 创伤 静脉注射 疗效 止血效果 

摘      要：Purpose: To compare the therapeutic effects of different doses of intravenous esomeprazole on treating trauma patients with stress ulcer bleeding. Methods: A total of 102 trauma patients with stress ulcer bleeding were randomly divided into 2 groups: 52 patients were assigned to the high-dose group who received 80 mg intravenous esomeprazole, and then 8 mg/h continuous infusion for 3 days; 50 patients were assigned to the conventional dose group who received 40 mg intravenous esomeprazole sodium once every 12 h for 72 h. Results: Compared with the conventional dose group, the total efficiency of the high-dose group and conventional dose group was 98.08% and 86.00%, respectively ( p 0.05), the hemostatic time was 22.10 h ± 5.18 h and 28.27 h ± 5.96 h, respectively ( p 0.05). Conclusion: Both doses of intravenous esomeprazole have good hemostatic effects on stress ulcer bleeding in trauma patients. The high-dose esomeprazole is better for hemostasis.