More or less is fine:an undercover work of DKK1 in anthrax toxin uptake

作     者：MAO BingYu WU Wei 

作者机构：State Key Laboratory of Genetic Resources and EvolutionKunming Institute of ZoologyChinese Academy of Sciences School of Life SciencesTsinghua University 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2014年第57卷第7期

页      面：735-736页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：炭疽毒素 卧底 吸收 前列腺癌细胞 受体相关蛋白 低密度脂蛋白 HeLa细胞 保护性抗原 

摘      要：The protective antigen(PA)mediated internalization of the anthrax complexes is critical in the development of anthrax,which depends on specific membrane receptors,namely ANTXR1(also known as TEM8)and ANTXR2(also known as CMG2)[1].In a screen for host proteins required for anthrax toxin action,low-density lipoprotein receptor-related protein 6(LRP6)was found important for efficient toxin entry in human M2182 prostate carcinoma cells[2],which interacts with both ANTXR1 and ***,the role of LRP6 in anthrax toxicity remains controversial as both in mice and in human HeLa cells,knockout or knockdown of LRP6 has no clear effect on their sensitivity to anthrax toxins[3].