Progress in human liver organoids

作     者：Lulu Sun Lijian Hui Lulu Sun;Lijian Hui

作者机构：State Key Laboratory of Cell BiologyChinese Academy of Sciences Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China Bio-Research Innovation CenterShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesSuzhou 215121China Institute for Stem Cell and RegenerationChinese Academy of SciencesBeijing 100101China School of Life Science and TechnologyShanghaiTech UniversityShanghai 201210China 

出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)

年 卷 期：2020年第12卷第8期

页      面：607-617页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This study is supported by the Chinese Academy of Sciences(XDA16020201 and XDA12050104) the National Science and Technology Major Project*Key New Drug Creation and Manufacturing Program,(2018ZX09711002-009) 

主　　题：liver organoid progress perspectives 

摘      要：Understanding the development,regeneration,and disorders of the liver is the major goal in liver *** mechanistic knowledge of human livers has been largely derived from mouse models and cell lines,which fall short in recapitulating the features of human liver cells or the structures and functions of human *** as an in vitro system hold the promise to generate organ-like tissues in a *** advances in human liver organoids also facilitate the understanding of the biology and diseases in this complex *** we review the progress in human liver organoids,mainly focusing on the methods to generate liver organoids,their applications,and possible future directions.