Ir/Phase-Transfer-Catalysis Cooperatively Catalyzed Asymmetric Cascade Allylation/2-aza-Cope Rearrangement: An Efficient Route to Homoallylic Amines from Aldimine Esters

作     者：Liang Wei Lu Xiao Zuo-Fei Wang Hai-Yan Tao Chun-Jiang Wang Liang Wei;Lu Xiao;Zuo-Fei Wang;Hai-Yan Tao;Chun-Jiang Wang

作者机构：College of Chemistry and Molecular SciencesWuhan UniversityWuhanHubei 430072China State Key Laboratory of Organometallic ChemistryShanghai Institute of Organic ChemistryShanghai 230021China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2020年第38卷第1期

页      面：82-86页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：This work was supported by NSFC(Nos.21525207,21772147) China Postdoctoral Science Foundation funded project(No.2017M620331).The Program of Introducing Talents of Discipline to Universities of China(111 Program)is also appreciated.We thank Prof.Shu-Li You at Shanghai Institute of Organic Chemistry(SIOC)for generously providing ligand THQPhos 

主　　题：system simplify catalysis 

摘      要：Summaryof main observation and conclusion Herein,we developed an Ir/phase-transfer-catalysiscooperatively catalyzed asymmetric cascade allyla-tion/2-aza-Cope rearrangement of aldimine esters to prepare synthetically important homoallylic amines in good yields with excellent *** with the bimetallic catalytic system to realize this transformation,the current cooperative Ir/tetrabutyl ammonium bromide catalytic system provides an alternative but more practical approach,which not only simplify the manipulation process but also increase the cost efficiency.