Mesenchymal stem cells in neurodegenerative diseases: Opinion review on ethical dilemmas

作     者：Matteo Scopetti Alessandro Santurro Vittorio Gatto Raffaele La Russa Federico Manetti Stefano D’Errico Paola Frati Vittorio Fineschi 

作者机构：Department of AnatomicalHistologicalForensic and Orthopaedic SciencesSapienza University of RomeRome 00185Italy Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)NeuromedSapienza University of RomaPozzilli 86077Italy UOC Risk ManagementQuality and AccreditationSant'Andrea University Hospital of RomeRome 00189Italy 

出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)

年 卷 期：2020年第12卷第3期

页      面：168-177页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：MSCs 

主　　题：Mesenchymal stem cells Neurodegenerative diseases Stem cell research Stem cell therapy Ethical principles Patient safety 

摘      要：The treatment of neurodegenerative diseases presents a growing need for innovation in relation to recent evidence in the field of reconstructive therapy using stem cells. Understanding the molecular mechanisms underlying neurodegenerative disorders, and the advent of methods able to induce neuronal stem cell differentiation allowed to develop innovative therapeutic approaches offering the prospect of healthy and perfectly functional cell transplants, able to replace the sick ones. Hence the importance of deepening the state of the art regarding the clinical applications of advanced cell therapy products for the regeneration of nerve tissue. Besides representing a promising area of tissue transplant surgery and a great achievement in the field of neurodegenerative disease, stem cell research presents certain critical issues that need to be carefully examined from the ethical perspective. In fact, a subject so complex and not entirely explored requires a detailed scientific and ethical evaluation aimed at avoiding improper and ineffective use, rather than incorrect indications, technical inadequacies, and incongruous expectations. In fact, the clinical usefulness of stem cells will only be certain if able to provide the patient with safe, long-term and substantially more effective strategies than any other treatment *** present paper provides an ethical assessment of tissue regeneration through mesenchymal stem cells in neurodegenerative diseases with the aim to rule out the fundamental issues related to research and clinical translation.