Impurity analysis of gentamicin bulk samples by improved liquid chromatography-ion trap mass spectrometry

作     者：ZHENG Chao WANG BoChu WANG MingJuan HOOGMARTENS Jos SCHEPDAEL Ann Van ADAMS Erwin 

作者机构：Bioengineering College of Chongqing University Chongqing 400030 China Katholieke Universiteit Leuven Faculteit Farmaceutische Wetenschappen Laboratorium voor Farmaceutische Analyse O&N2 PB 923 Herestraat 49 B-3000 Leuven Belgium National Institute for Control of Pharmaceutical and Biological Products Beijing 100050 China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2011年第54卷第9期

页      面：1518-1528页

核心收录：

学科分类：090403[农学-农药学(可授农学、理学学位）] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 09[农学] 0904[农学-植物保护] 0703[理学-化学] 070301[理学-无机化学] 

主　　题：gentamicin liquid chromatography LC/MS impurity analysis 

摘      要：Several gentamicin bulk samples from different origins were investigated using an LC/MS *** equipped with ion trap MS with positive ionization was performed on a Capcell Pak C18(AQ) column with the mobile phase containing 50 mM trifluoroacetic(TFA) and *** present in batches of gentamicin bulk samples were elucidated and compared according to their fragmentation *** total seventeen impurities present in samples,five impurities were not elucidated and two compounds were identified *** was observed that the impurity profiles were different in samples from different origins which indicate necessity in the quality control of gentamicin.