CircRNA expression profiles in decidual tissue of patients with early recurrent miscarriage

作     者：Chunli Li Xuemei Chen Xueqing Liu Xiaoli Liu Junlin He Yubin Ding Chao Tong Chuan Peng Yingxiong Wang Rufei Gao 

作者机构：Laboratory of Reproductive BiologySchool of Public Health and ManagementChongqing Medical UniversityChongqing400016China Department of Clinical LaboratoryChongqing Health Center for Women and ChildrenChongqing401174China Joint International Research Laboratory of Reproduction&DevelopmentChongqing Medical UniversityChongqing400016China Department of Family PlanningChongqing Health Center for Women and ChildrenChongqing401174PR China Department of ObstetricsThe First Affiliated Hospital of Chongqing Medical UniversityChongqing400016China Laboratory of Maternal and Fetal MedicineThe First Affiliated Hospital of Chongqing Medical UniversityChongqing400016China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2020年第7卷第3期

页      面：414-423页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100211[医学-妇产科学] 0703[理学-化学] 10[医学] 

基　　金：The authors would like to thank all the members of our research group for their technical support This work was supported by the National Natural Science Foundation of China(no 31771663) 

主　　题：Circular RNAs Decidual tissue Early recurrent miscarriage Expression profiles Microarray 

摘      要：Circular RNAs(circRNAs)are a novel class of endogenous noncoding RNAs that play important roles in gene expression *** study aimed to evaluate the potential role of circRNAs in decidual tissue of patients with early recurrent miscarriage(RM).We constructed circRNA expression profiles in decidual tissue using microarray data.A total of 123 differentially expressed circRNAs,including 78 upregulated and 45 downregulated circRNAs were detected in the early RM group compared with the control group(P0.05).Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis also revealed the enrichment of specific *** verified circRNA-targeted miRNA-mRNA network was constructed,most of the circRNAs harbored miRNA binding *** network involved 3 circRNAs,27 microRNAs and 82 ***_circRNA_103092-miR-224-PRLR network was selected to verify by *** results showed that circRNAs are aberrantly expressed in the decidual tissue in early RM patients and play potential roles in the development of early *** gives new insights into the mechanism of recurrent miscarriage.