NHC-catalyzed Redox-Neutral Aza-Benzoin Reaction of Aldehydes with Tetrahydroisoquinolines

作     者：Di Jiang Zijun Wu Jian Wang Di Jiang;Zijun Wu;Jian Wang

作者机构：School of Pharmaceutical SciencesKey Laboratory of Bioorganic Phosphorous Chemistry&Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing 100084China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2020年第38卷第2期

页      面：135-138页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the National Natural Science Foundation of China(Nos.21672121 and 21871160) the"Thousand Plan"Youth Program of China,Tsinghua University,the Bayer Investigator Fellowship,and the Fellowship of Tsinghua-Peking Centre for Life Sciences(CLS) 

主　　题：materials. quinoline aldehydes 

摘      要：Summary of main observation and conclusion Tetrahydroisoquinoline derivatives are useful synthetic intermediates,which play an important role in the preparation of natural products,pharmaceuticals and other ***,we report an unprecedented redox-neutral aza-benzoin protocol to construct such *** exposure of tetrahydroisoquinolines to aromatic aldehydes in the prese nee of an NHC catalyst,the C-l acylated tetra hydroisoquinolines were obtained in moderate to good yields.