Synthesis of difluoromethylated benzylborons via rhodium(Ⅰ)-catalyzed fluorine-retainable hydroboration of gem-difluoroalkenes

作     者：Yuanhong Cai Donghang Tan Qiqi Zhang Wenxin Lv Qingjiang Li Honggen Wang Yuanhong Cai;Donghang Tan;Qiqi Zhang;Wenxin Lv;Qingjiang Li;Honggen Wang

作者机构：Guangdong Provincial Key Laboratory of Chiral Molecule and Drug DiscoverySchool of Pharmaceutical SciencesSun Yat-sen University.Guangzhou 510006China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesSchool of Chemistry and Pharmaceutical Sciences of Guangxi Normal UniversityGuilin 541004China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2021年第32卷第1期

页      面：417-420页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0703[理学-化学] 10[医学] 

基　　金：financial support from the National Natural Science Foundation of China(No.21971261) Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery(No.2019B030301005) Key Project of Chinese National Programs for Fundamental Research and Development(No.2016YFA0602900) the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(No.2017BT01Y093)is gratefully acknowledged 

主　　题：Rhodium Hydroboration Difluoromethy gem-Difluoroalkene β-F elimination 

摘      要：The synthesis of bo rylated orga nofluorines is of great interest due to their potential values as synthons in modular construction of fluorine-containing *** herein is a rhodium-catalyzed hydrobo ration of arylgem-difluoroalkenes leading to a series of α-difluoromethylated *** use of cationic rhodium catalyst and a biphosphine ligand with large bite angle was crucial for reactivity by offering good regioselectivity and diminishing the undesired β-F *** derivatizations of the products were conducted to showcase the utility of this protocol.