Neuroprotective effects of a ketogenic diet in combination with exogenous ketone salts following acute spinal cord injury

作     者：Bo-Tao Tan Hui Jiang Aaron JMoulson Xiao-Liang Wu Wen-Chun Wang Jie Liu Ward TPlunet Wolfram Tetzlaff 

作者机构：Department of Rehabilitation MedicineThe Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina International Collaboration on Repair Discoveries(ICORD)Blusson Spinal Cord CenterVancouverBritish ColumbiaCanada Department of ZoologyUniversity of British ColumbiaVancouverBritish ColumbiaCanada Department of Spinal SurgeryNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation MedicineThe General Hospital of Western Theater Command PLAChengduSichuan ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第10期

页      面：1912-1919页

核心收录：

学科分类：1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100215[医学-康复医学与理疗学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the Craig Neilsen Foundation(to WT) the Canadian Institutes for Health Research(to WT) supported by the China Scholarship Council(No.201508500102) a visiting trainee stipend from the Blusson Integrated Cure Partnership the John and Penny Ryan British Columbia Leadership Chair in Spinal Cord Research funded in part by the Rick Hansen Foundation 

主　　题：axon behavior corticospinal tract ketogenic diet ketone supplementation myelin neuroprotection spinal cord injury 

摘      要：We have previously shown that induction of ketosis by ketogenic diet(KD)conveyed neuroprotection following spinal cord injury in rodent models,however,clinical translation may be limited by the slow raise of ketone levels when applying KD in the acute post-injury *** we investigated the use of exogenous ketone supplementation(ketone sodium,KS)combined with ketogenic diet as a means rapidly inducing a metabolic state of ketosis following spinal cord injury in adult *** uninjured rats,ketone levels increased more rapidly than those in rats with KD alone and peaked at higher levels than we previously demonstrated for the KD in models of spinal cord ***,ketone levels in KD+KS treated rats with SCI did not exceed the previously observed levels in rats treated with KD *** still demonstrated neuroprotective effects of KD+KS treatment that extend our previous neuroprotective observations with KD *** results showed increased neuronal and axonal sparing in the dorsal corticospinal ***,better performance of forelimb motor abilities were observed on the Montoya staircase(for testing food pellets reaching)at 4 and 6 weeks post-injury and rearing in a cylinder(for testing forelimb usage)at 6 and 8 weeks *** together,the findings of this study add to the growing body of work demonstrating the potential benefits of inducing ketosis following *** salt combined with a ketogenic diet gavage in rats with acute spinal cord injury can rapidly increase ketone body levels in the blood and promote motor function *** study was approved by the Animal Care Committee of the University of British Columbia(protocol No.A14-350)on August 31,2015.