Prion Protein Expression is Correlated with Glioma Grades

作     者：Qiaoli Luo Yisong Wang Dongying Fan Shijie Wang Peigang Wang Jing An Qiaoli Luo;Yisong Wang;Dongying Fan;Shijie Wang;Peigang Wang;Jing An

作者机构：Department of MicrobiologySchool of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Center of EpilepsyBeijing Institute for Brain DisordersBeijing 100093China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2020年第35卷第4期

页      面：490-493页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the following funds:the National Natural Science Foundation of China(81671971,81871641 and 81701992) the Beijing Natural Science Foundation Program Scientific Research Key Program of Beijing Municipal Commission of Education(KZ201810025035) 

主　　题：glioma al. Glioma 

摘      要：Dear Editor,Glioma is the most common primary central nervous system(CNS)tumors in *** are classified into low-grade glioma(LGG,grades I–II)and high-grade glioma(HGG,grades III–IV)according to the World Health Organization classification guidelines(Louis et al.2007).Comparing to the LGG,the HGG becomes more aggressive and has a poorer median overall *** present,glioma is mainly treated by radiotherapy,chemotherapy and surgical resection,but the effect is not ideal,especially for the glioblastoma(GBM),which is the most malignant type of gliomas and is resistant to current therapy *** are several theories about the pathogenesis of glioma,such as radiation(Ohgaki and Kleihues 2005)。