Laos is Affected by HIV CRF01_AE and the Newly Identified CRF97_01B

作     者：Xin Chen Mei Ye Yu Wang Chiyu Zhang Yong-Tang Zheng Xin Chen;Mei Ye;Yu Wang;Chiyu Zhang;Yong-Tang Zheng

作者机构：Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan ProvinceNational Kunming High Level Biosafety Research Center for Non-human PrimateKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Department of Pathogenic BiologySchool of Basic Medical SciencesGannan Medical UniversityGanzhou 341000China KIZ-SU Joint Laboratory of Animal Models and Drug DevelopmentCollege of Pharmaceutical SciencesSoochow UniversitySuzhou 215006China Pathogen Discovery and Evolution UnitPathogen Discovery and Big Data CenterInstitut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2020年第35卷第5期

页      面：538-547页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported in part by Grants from the National Natural Science Foundation of China(U1302224 81601802 81271892 81902106) 

主　　题：Human immunodeficiency virus(HIV) Subtype CRF01_AE CRF9701B Epidemiology Laos 

摘      要：Laos is the only landlocked country in Southeast Asia and borders Thailand,Myanmar and Cambodia,the three countries in this region that have been hardest hit by human immunodeficiency virus(HIV).Laos has been regarded as a low-HIVprevalence country for *** understand the status of HIV in Laos in recent years,a retrospective study was performed among 2851 patients visiting a hospital in Vientiane,the capital of Laos,from November 2011 to May *** blood samples were obtained from the patients,and DNA was *** status was determined by HIV gag fragment-specific PCR ***-nine samples were detected as HIV proviral DNA positive with a positive rate of 2.4%(69/2851).Sixty-one near full-length genomic sequences were obtained from the positive *** results of phylogenetic analysis showed that the vast majority(91.8%)of the HIV strains belonged to CRF01AE,and the other five(8.2%)strains were identified as a new HIV circulating recombinant form CRF9701B,which had a CRF01AE backbone with an insertion of subtype B in the gag-pol *** analysis revealed that HIV CRF01AE circulating in Laos were multiply introduced from *** results indicated that Laos might be suffering a considerably more serious impact of HIV than previously *** keep this country from undergoing the same increase in HIV prevalence observed in its neighbors,immediate intervention measures and sufficient epidemiological research are urgently needed.