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Age-related histomorphologic changes in the canine gastrointestinal tract:A histologic and immunohistologic study

Age-related histomorphologic changes in the canine gastrointestinal tract:A histologic and immunohistologic study

作     者:Berit Baum Felix Meneses Sven Kleinschmidt Ingo Nolte Marion Hewicker-Trautwein 

作者机构:Department of Pathology University of Veterinary Medicine Hannover Germany Clinic for Small Animals University of Veterinary Medicine Hannover Germany 

出 版 物:《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文版))

年 卷 期:2007年第13卷第1期

页      面:152-157页

核心收录:

学科分类:1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基  金:Supported by the German Research Council (He 1548/4-2) 

主  题:Age, Canine, Intestine Ki67 Stomach 

摘      要:AIM: To examine the of the gastric, jejuna physiological aging. changes in the histomorphology and colonic wall of dogs due to METHODS: Full thickness biopsies were taken from the gastrointestinal tracts of 28 dogs of different ages. The thickness of the different layers of the wall was measured and the numbers of proliferating cells as indicated by immunohistochemical detection of Ki67 were counted. RESULTS: In the three excision sites, the thickness of all subepithelial layers increased with rising age. The strongest correlation between age and thickness of the intestinal wall was found in the first 10 years of life and in the jejunum (r =0.6-0.71 for the deep lamina propria mucosa, the muscularis mucosa, and the circular layer of the tunica muscularis). The number of proliferating cells decreased during aging, with the strongest correlation in the lamina propria mucosa and lamina muscularis mucosa of the jejunum and in the colonic submucosa (r =-0.61 to -0.71). Epithelial proliferation was only weakly correlated to the age. CONCLUSION: The morphology of the deeper layers and the proliferation of mesenchymal cells of the intestinal wall of healthy dogs are correlated with age. Gastrointestinal epithelial proliferation is only weakly age-correlated.

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