Halloysite nanotubes loaded with nano silver for the sustained-release of antibacterial polymer nanocomposite scaffolds

作     者：Wang Guo Wei Liu Li Xu Pei Feng Yanru Zhang Wenjing Yang Cijun Shuai Wang Guo;Wei Liu;Li Xu;Pei Feng;Yanru Zhang;Wenjing Yang;Cijun Shuai

作者机构：aState Key Laboratory of High Performance Complex ManufacturingCollege of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China Department of Metabolism and EndocrinologyThe Second Xiangya HospitalCentral South UniversityChangsha 410011China School of Basic Medical ScienceCentral South UniversityChangsha 410013China Institute of Bioadditive ManufacturingJiangxi University of Science and TechnologyNanchang 330013China Shenzhen Institute of Information TechnologyShenzhen 518172China 

出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)

年 卷 期：2020年第42卷第11期

页      面：237-247页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 0817[工学-化学工程与技术] 0806[工学-冶金工程] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0802[工学-机械工程] 0801[工学-力学（可授工学、理学学位）] 0702[理学-物理学] 10[医学] 

基　　金：the National Natural Science Foundation of China(Nos.51935014,51905553,81871494,81871498,51705540) the Hunan Provincial Natural Science Foundation of China(Nos.2019JJ50774,2018JJ3671 and 2019JJ50588) the Jiang Xi Provincial Natural Science Foundation of China(No.20192ACB20005) the Guangdong Province Higher Vocational Colleges&Schools Pearl River Scholar Funded Scheme(2018) the Open Sharing Fund for the Large-scale Instruments and Equipments of Central South University the Project of Hunan Provincial Science and Technology Plan(No.2017RS3008) the Hunan Provincial Innovation Foundation For Postgraduate(No.CX2018B093) the Fundamental Research Funds for the Central Universities of Central South University(Nos.2018zzts022 and 2019zzts725) 

主　　题：Halloysite nanotubes Nano silver Sustained-release Antibacterial properties Polymer nanocomposite scaffolds 

摘      要：It is challenging for antibacterial polymer scaffolds to achieve the drug sustained-release through directly coating or *** this work,halloysite nanotubes(HNTs),a natural aluminosilicate nanotube,were utilized as a nano container to load nano silver(Ag)into the lumen through vacuum negativepressure suction&injection and thermal decomposition of silver ***,the nano Ag loaded HNTs(HNTs@Ag)were introduced to poly-l-lactic acidide)(PLLA)scaffolds prepared by additive manufacturing for the sustained-release of Ag^+.Acting like a’shield’,the tube walls of HNTs not only retarded the erosion of external aqueous solution on internal nano Ag to generate Ag^+but also postponed the generated Ag^+to diffuse *** results indicated the PLLA-HNTs@Ag nanocomposite scaffolds achieved a sustained-release of Ag^+over 28 days without obvious initial burst ***,the scaffolds exhibited a long-lasting antibacterial property without compromising the ***,the degradation properties,biomineralization ability and mechanical properties of the scaffolds were *** study suggests the potential application of inorganic nanotubes as drug carrier for the sustained-release of functional polymer nanocomposite scaffolds.