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A comparative study of two porous sponge scaffolds prepared by collagen derived from porcine skin and fish scales as burn wound dressings in a rabbit model

作     者:Yufei Shi Hongjian Zhang Xin Zhang Zhan Chen Dan Zhao Jun Ma 

作者机构:Advanced Biomaterials and Tissue Engineering CenterHuazhong University of Science and TechnologyWuhan 430074China Department of Biomedical EngineeringCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China 

出 版 物:《Regenerative Biomaterials》 (再生生物材料(英文版))

年 卷 期:2020年第7卷第1期

页      面:63-70页

核心收录:

学科分类:0831[工学-生物医学工程(可授工学、理学、医学学位)] 08[工学] 0836[工学-生物工程] 

基  金:This work was supported by the National Key R&D Program of China(grant no.2018YFC1105700,2018YFC1105701) the National Natural Science Foundation of China(grant no.31570965).We are grateful to the Analytical and Testing Center(HUST) 

主  题:collagen wound dressings wound healing 

摘      要:Collagen is widely used in biomedical applications due to its outstanding *** this study,highly porous sponge scaffolds were developed by using porcine skin-derived collagen(PSC)and fish scale-derived collagen(FSC),*** morphology and composition of these PSC and FSC scaffolds were *** water uptake ratio of FSC scaffolds reached 47.8,which is 1.7 times of PSC *** water vapour transmission rates(WVTR)of PSC and FSC scaffolds were 952.6655.5 and 1090.9677.1 g/m2/day,which could produce a moist healing environment for *** scaffolds show non-toxicity to L929 fibroblast *** burn wound healing efficiency of these two scaffolds was examined in vivo using *** scars around the wounds were observed after applying PSC and SFC *** studies reveal that the wound treated with PSC and FSC scaffolds showed much better wound recovery than gauze and vaseline gauze *** was suggested that FSC scaffolds have great potential as same as PSC to be used as burn wound dressing materials.

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