A comparative study of two porous sponge scaffolds prepared by collagen derived from porcine skin and fish scales as burn wound dressings in a rabbit model
作者机构:Advanced Biomaterials and Tissue Engineering CenterHuazhong University of Science and TechnologyWuhan 430074China Department of Biomedical EngineeringCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China
出 版 物:《Regenerative Biomaterials》 (再生生物材料(英文版))
年 卷 期:2020年第7卷第1期
页 面:63-70页
核心收录:
学科分类:0831[工学-生物医学工程(可授工学、理学、医学学位)] 08[工学] 0836[工学-生物工程]
基 金:This work was supported by the National Key R&D Program of China(grant no.2018YFC1105700,2018YFC1105701) the National Natural Science Foundation of China(grant no.31570965).We are grateful to the Analytical and Testing Center(HUST)
主 题:collagen wound dressings wound healing
摘 要:Collagen is widely used in biomedical applications due to its outstanding *** this study,highly porous sponge scaffolds were developed by using porcine skin-derived collagen(PSC)and fish scale-derived collagen(FSC),*** morphology and composition of these PSC and FSC scaffolds were *** water uptake ratio of FSC scaffolds reached 47.8,which is 1.7 times of PSC *** water vapour transmission rates(WVTR)of PSC and FSC scaffolds were 952.6655.5 and 1090.9677.1 g/m2/day,which could produce a moist healing environment for *** scaffolds show non-toxicity to L929 fibroblast *** burn wound healing efficiency of these two scaffolds was examined in vivo using *** scars around the wounds were observed after applying PSC and SFC *** studies reveal that the wound treated with PSC and FSC scaffolds showed much better wound recovery than gauze and vaseline gauze *** was suggested that FSC scaffolds have great potential as same as PSC to be used as burn wound dressing materials.