An ironic case of liver infections:Yersinia enterocolitis in the setting of thalassemia

作     者：Nathan Selsky Faripour Forouhar George Y Wu 

作者机构：Division of Gastroenterology and HepatologyDepartment of MedicineUniversity of Connecticut Health Center Department of Anatomic PathologyUniversity of Connecticut Health Center 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第37期

页      面：6296-6298页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Yersinia Enterocolitis Bone marrow Liver biopsy Thalassemia Hemophagocytic lymphohistiocytosis 

摘      要：A 49 years old Vietnamese male with a history of thalassemia,presented with gastrointestinal symptoms and signs of hemolysis.He was diagnosed with yersinia enterocolitis.Yersinia is a gram-negative rod that most frequently occurs in children especially during the winter months.In the current case,the bone marrow biopsy showed hemophagocytosis along with positive cultures for Yersinia.The microorganism likely triggered hemophagocytosis.This syndrome,also known as,hemophagocytic lymphohistiocytosis,is defined by fever for more than 7 d,cytopenia of two or more cell lines,hemophagocytosis,hepatitis,serum ferritin greater than500,jaundice,lymphadenopathy,and hepatosplenomegaly.This disorder can be either familial or secondary to a strong immunologic activation.Both have an overwhelming activation of T-cells and macrophages.