Evolution of Artificial Base Pairs with Hydrogen Bond Complementarity
作者机构：Institute of Molecular MedicineState Key laboratory of Oncogenes and Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127P.R.China Key Laboratory for Analytical Science of Food Safety and BiologyMinistry of EducationFujian Provincial Key Laboratory of Analysis and Detection Technology for Food SafetyState Key Laboratory of Photocatalysis on Energy and EnvironmentCollege of ChemistryFuzhou UniversityFuzhou 350108.P.R.China
出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)
年 卷 期：2020年第36卷第2期
页 面：151-156页
核心收录：
基 金：Supported by the National Natural Science Foundation of Chino(Nos.21622502,21702136) the Natural Science Foundation of Fujian Province,China(No.2017J06004) the Shanghai Rising-star Program,China(No.19QA1405400)
主 题：Artificial base pair Nucleic add Hydrogen bonding base pair Hydrophobic base pair Metal-base pair Aptamcr
摘 要：Artificial base pairs,from the perspective of synthetic biology,are designed to contain the features of modularity,orthogonality,and *** the development of artificial base pairs has beat endowed with responsibility to understand the biological process,improve the recognition capacity and stability of aptamers,and develop the nucleoside drugs,diagnosis,and drag *** this review,we first gave a concise introduction of artificial base pairs based on their interaction modes including alternative hydrogen bonding,hydrophobic interaction,and metal *** we displayed the detailed information of artificial base pairs with hydrogen bonding interaction,and analyzed how the changes of their structures affect their ***,we highlighted the applications of functional artificial base pairs in aptamer discovery,diagnosis,and drug ***,an insight into the remaining challenges and future perspective of the artificial bases was provided.
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