Yogurt Intake Reduces All-Cause and Cardiovascular Disease Mortality: A Meta-Analysis of Eight Prospective Cohort Studies

作     者：GAO Xiang JIA Hai-yi CHEN Guo-chong LI Cheng-yue HAO Mo GAO Xiang;JIA Hai-yi;CHEN Guo-chong;LI Cheng-yue;HAO Mo

作者机构：Research Institute of Health Development StrategiesFudan UniversityShanghai(200032)China School of Public HealthXuzhou Medical UniversityXuzhou(221004)China School of Public Health and ManagementWeifang Medical UniversityWeifangShandong Province(261053)China Department of Epidemiologyand Population HealthAlbert Einstein College of MedicineNY(10461)USA 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2020年第26卷第6期

页      面：462-468页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by the Shanghai Three-Year Action Plan for Strengthening Public Health System Construction(2015-2017)(No.GWIV-32) 

主　　题：yogurt mortality cardiovascular disease cancer meta-analysis 

摘      要：Objective:To assess the relationship between yogurt intake and mortality risk from prospective cohort ***:The PubMed,EMBASE,and Web of Science databases were searched for all records related to yogurt intake and mortality risk[all-cause or cardiovascular disease(CVD)or cancer mortality]before October 1,*** Newcastle-Ottawa Quality Scale was used to estimate the quality of all eligible *** results of the highest and lowest categories of yogurt intake in each study were collected and the effect size was pooled using a random effects *** dose-response analysis was calculated using the generalized least squares trend estimation ***:Eight eligible cohort studies were included in this *** were 235,676 participants in the 8 studies,and the number of deaths was 14,*** with the lowest category,the highest category of yogurt intake was not significantly related with all cause mortality[hazard ratio(HR)=0.93;95%confidence interval(CI):0.85,1.01],CVD mortality(HR=0.92;95%CI:0.81,1.03)and cancer mortality(HR=0.97;95%CI:0.83,1.12).These studies were homogenous,since the homogeneity test showed that I2 was 28.7%,15.1%and 11.8%,***,yogurt intake 200 g/d was significantly associated with a lower all-cause mortality(HR=0.88;95%CI:0.80,0.96)and CVD mortality(HR=0.87;95%CI:0.77,0.99)in the subgroup *** dose-response analysis showed that yogurt intake of 200 g/d was inversely associated with all-cause mortality(P=0.041,HR=0.95,95%CI:0.92,1.00)and CVD mortality(P=0.009,HR=0.92,95%CI:0.86,0.98),and all of which were linear relationship(P0.05).Conclusions:This review provided the evidence regarding yogurt intake can reduce all-cause and CVD *** some positive findings were identified,more high-quality cohort studies and randomized controlled trials are warranted on a possible protective effect of yoghurt on health.